Chief Physician · Researcher · Doctoral Supervisor
Clinical practice in traumatic brain injury and neurocritical care. Research in neuroprotection, neural repair and multicentre clinical trials.
Director of Neurosurgery and the Brain Injury Center at Renji Hospital. Clinical work covers traumatic brain injury, cerebral haemorrhage, neurocritical illness, disorders of consciousness and complications after brain injury.
Mechanisms, neuroprotection & repair
Basic research examines cellular injury and metabolism, neural regeneration, and delivery strategies for neuroprotection and repair. The programme connects molecular studies with cell and animal models.
Surgical decisions, critical care & outcomes
Clinical research addresses operative decisions, intensive care and outcomes after traumatic brain injury, through multicentre trials, clinical cohorts, prediction models and evidence synthesis.
Multicentre randomised controlled trial · 28 hospitals
Decompressive craniectomy did not improve six-month functional outcomes and increased delayed intracranial haemorrhage in the population studied.
Publication detailsMolecular and cellular mechanism study
Biochemical, genetic and cellular experiments identified N-terminal SUMOylation of cofilin-1 and showed that it promotes binding to F-actin and actin depolymerisation.
Publication detailsPreclinical study · nanoparticle–hydrogel delivery
An antioxidant nanoparticle–hydrogel system delivered a CSF-1R inhibitor at the injury site. Experimental work examined its effects on microglia and secondary neuroinflammation.
Publication detailsDoctoral supervision connecting neurotrauma practice, basic science and clinical research.
Research directions & enquiriesCo-author of 大脑环游记：漫画神经科学的奇妙世界, an illustrated neuroscience book published by Tsinghua University Press.
Books & community education