Basic and clinical research in brain injury, with representative work and a publication catalogue.
Mechanisms, neuroprotection & repair
Basic research examines cellular injury and metabolism, neural regeneration, and delivery strategies for neuroprotection and repair. The programme connects molecular studies with cell and animal models.
Surgical decisions, critical care & outcomes
Clinical research addresses operative decisions, intensive care and outcomes after traumatic brain injury, through multicentre trials, clinical cohorts, prediction models and evidence synthesis.
Sole and co-corresponding authorship across basic and clinical research.
Selected publications across brain injury mechanisms, neural repair and clinical evidence.
Multicentre randomised controlled trial · 28 hospitals
Does decompressive craniectomy improve outcomes over standard craniotomy for large acute epidural haematoma with tentorial herniation?
Decompressive craniectomy did not improve six-month functional outcomes and increased delayed intracranial haemorrhage in the population studied.
Publication detailsReview · epidemiology, care pathways and clinical research
How have traumatic brain injury care and research in China evolved since the 2019 review?
The review examines changes in injury patterns, care pathways and clinical research, and discusses regional differences in access to specialist services and training.
Publication detailsProspective multicentre cohort · 52 hospitals, 13,138 patients
What patterns of injury, treatment and outcomes emerge across Chinese neurosurgical centres?
This national registry characterised patients and outcomes across hospitals, identifying variation between centres and regions and providing a foundation for comparative clinical research.
Publication detailsMolecular and cellular mechanism study
How does SUMO modification at the N-terminal amino group regulate cofilin-1 and actin dynamics?
Biochemical, genetic and cellular experiments identified N-terminal SUMOylation of cofilin-1 and showed that it promotes binding to F-actin and actin depolymerisation.
Publication detailsPreclinical study · nanoparticle–hydrogel delivery
Can a locally applied carrier improve the specificity of an intervention directed at microglia?
An antioxidant nanoparticle–hydrogel system delivered a CSF-1R inhibitor at the injury site. Experimental work examined its effects on microglia and secondary neuroinflammation.
Publication detailsPreclinical study · cell and mouse models
Can a neurophilic biomimetic lipoprotein carrier improve nerve growth factor delivery after brain injury?
The study explored brain-targeted delivery and neural repair in experimental models, providing preclinical evidence for further translational investigation.
Publication detailsMechanistic study · human tissue, cells and mouse models
Does injury-induced protein lactylation link metabolic stress to neuronal apoptosis?
Tufm K286 lactylation suppressed mitophagy and increased neuronal apoptosis. A lactylation-deficient mutation and mild hypothermia improved experimental outcomes in mice.
Publication detailsPreclinical biomaterials study
Can an intraoperatively applied hydrogel address oxidative stress and disrupted energy metabolism together?
A reactive-oxygen-responsive hydrogel combined ROS scavenging with 2-deoxyglucose release. Cell and animal experiments examined its effects on oedema, inflammation and neuronal injury.
Publication detailsSystematic review & meta-analysis · 105 studies
How do mortality and associated risk factors vary among older adults with traumatic brain injury?
The review included approximately 2.22 million patients from 30 countries and regions, examining mortality by injury severity, geography and patient characteristics.
Publication detailsRegistry-based modelling · 52 centres, 2,631 patients
Can early clinical information estimate mortality within 14 days of severe traumatic brain injury?
A nomogram was developed in 1,808 patients and independently validated in 823 patients from different centres, with a validation AUC of 0.856.
Publication detailsMechanistic and preclinical study
Can enhancing endothelial oxidative phosphorylation protect the blood–brain barrier after traumatic brain injury?
The study investigated fenofibrate, a PPARα agonist, and linked enhanced endothelial oxidative phosphorylation to protection of the blood–brain barrier and reduced post-traumatic oedema in experimental models.
Publication detailsExplore trials, clinical cohorts, reviews and commentary, including first-author and collaborative contributions.
Browse all indexed publications, or filter by corresponding authorship and other contributions.