Basic research

Fenofibrate alleviates the brain edema after traumatic brain injury by enhancing endothelial OXPHOS.

Feng Q, Gao Y, Gu X, Zhao X, Liu X, Ma Z, Qi W, He Z, Han Y, Zhang J, Wang W, Li Z, Zhang D, Huang J, Lin Y, Hui J, Onondari B, Erdenetsetseg G, Mao Q, Jiang J, Zhou Y, Weng W, Zhang Y, Feng J.

Redox Biology. 2026;94:104240

Junfeng Feng: Co-corresponding author

DOI: 10.1016/j.redox.2026.104240

Intracranial Photostimulation Relieves the Learning and Memory Impairment after Traumatic Brain Injury.

Qi W, Hui J, He Z, Feng Q, Gu X, Wang J, Huang J, Lin Y, Ge B, Weng W, Gao Y, Feng J.

Journal of Neurotrauma. 2026;43(15-16):1352-1365

Junfeng Feng: Co-corresponding author

DOI: 10.1177/08977151251406247

Dynein-regulated brain transduction of AAV.CAP-B10 via cerebral lateral ventricle enhances hippocampal function after traumatic brain injury through Ngf gene delivery in mice.

Wang JC, Ding SH, He ZH, Huang JL, Weng WJ, Gao YW, Jiang JY, Lin Y, Feng JF.

Experimental Neurology. 2025;391:115285

Junfeng Feng: Author

DOI: 10.1016/j.expneurol.2025.115285

Intraoperative application of an antioxidant nanoparticle-hydrogel targeting microglia regulates neuroinflammation in traumatic brain injury.

Han Y, Gu J, Xu M, Ma Y, Weng W, Feng Q, He Z, Qi W, Mao Q, Jiang J, Feng J.

Journal of Nanobiotechnology. 2025;23(1):599

Junfeng Feng: Sole corresponding author

DOI: 10.1186/s12951-025-03682-7

Neurophilic Biomimetic Lipoprotein-Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy.

Huang J, Wang W, Peng Y, Weng W, Wei H, Feng Q, Wang A, Hu M, Li Z, Sun S, He Z, Zhang D, Qi W, Han Y, Ma Z, Hui J, Gong R, Gao Y, Lin Y, Jiang J, Gao X, Feng J.

Advanced Science. 2025;12(42):e09405

Junfeng Feng: Sole corresponding author

DOI: 10.1002/advs.202509405

Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury.

Weng W, He Z, Ma Z, Huang J, Han Y, Feng Q, Qi W, Peng Y, Wang J, Gu J, Wang W, Lin Y, Jiang G, Jiang J, Feng J.

Cell Death & Differentiation. 2025;32(3):530-545

Junfeng Feng: Sole corresponding author

DOI: 10.1038/s41418-024-01408-0

An injectable refrigerated hydrogel for inducing local hypothermia and neuroprotection against traumatic brain injury in mice.

Han Y, Han Z, Huang X, Li S, Jin G, Feng J, Wu D, Liu H.

Journal of Nanobiotechnology. 2024;22(1):251

Junfeng Feng: Co-corresponding author

DOI: 10.1186/s12951-024-02454-z

Brain Delivery of Protein Therapeutics by Cell Matrix-Inspired Biomimetic Nanocarrier.

Huang J, Fu Y, Wang A, Shi K, Peng Y, Yi Y, Yu R, Gao J, Feng J, Jiang G, Song Q, Jiang J, Chen H, Gao X.

Advanced Materials. 2024;36(31):e2405323

Junfeng Feng: Author

DOI: 10.1002/adma.202405323

Intraoperative application of intelligent, responsive, self-assembling hydrogel rectifies oxygen and energy metabolism in traumatically injured brain.

Han Y, Weng W, Zhang Y, Feng Q, Ma Y, Quan A, Fu X, Zhao X, Skudder-Hill L, Jiang J, Zhou Y, Chen H, Feng J.

Biomaterials. 2024;306:122495

Junfeng Feng: Co-corresponding author

DOI: 10.1016/j.biomaterials.2024.122495

Mild hypothermia promotes neuronal differentiation of human neural stem cells via RBM3-SOX11 signaling pathway.

Ma Y, He Z, Wang J, Zheng P, Ma Z, Liang Q, Zhang Q, Zhao X, Huang J, Weng W, Jiang J, Feng J.

iScience. 2024;27(4):109435

Junfeng Feng: Co-corresponding author

DOI: 10.1016/j.isci.2024.109435

Self-Disassembling and Oxygen-Generating Porphyrin-Lipoprotein Nanoparticle for Targeted Glioblastoma Resection and Enhanced Photodynamic Therapy.

Chen Y, Ma Y, Shi K, Chen H, Han X, Wei C, Lyu Y, Huang Y, Yu R, Song Y, Song Q, Jiang J, Feng J, Lin Y, Chen J, Chen H, Zheng G, Gao X, Jiang G.

Advanced Materials. 2024;36(15):e2307454

Junfeng Feng: Author

DOI: 10.1002/adma.202307454

Temperature induces brain-intake shift of recombinant high-density lipoprotein after traumatic brain injury.

Huang J, Peng Y, Wang X, Gu X, Yi Y, Wang W, He Z, Ma Z, Feng Q, Qi W, Hui J, Gong R, Weng W, Jiang G, Gao Y, Lin Y, Li J, Jiang J, Feng J.

Journal of Nanobiotechnology. 2024;22(1):769

Junfeng Feng: Co-corresponding author

DOI: 10.1186/s12951-024-03016-z

N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization.

Weng W, Gu X, Yang Y, Zhang Q, Deng Q, Zhou J, Cheng J, Zhu MX, Feng J, Huang O, Li Y.

Nature Communications. 2023;14(1):5688

Junfeng Feng: Co-corresponding author

DOI: 10.1038/s41467-023-41520-2

Recombinant High-Density Lipoprotein Boosts the Therapeutic Efficacy of Mild Hypothermia in Traumatic Brain Injury.

Huang J, Zhu H, Yu P, Ma Y, Gong J, Fu Y, Song H, Huang M, Luo J, Jiang J, Gao X, Feng J, Jiang G.

ACS Applied Materials & Interfaces. 2023;15(1):26-38

Junfeng Feng: Co-corresponding author

DOI: 10.1021/acsami.2c02940

Brain Extract of Subacute Traumatic Brain Injury Promotes the Neuronal Differentiation of Human Neural Stem Cells via Autophagy.

He Z, Lang L, Hui J, Ma Y, Yang C, Weng W, Huang J, Zhao X, Zhang X, Liang Q, Jiang J, Feng J.

Journal of Clinical Medicine. 2022;11(10):2709

Junfeng Feng: Sole corresponding author

DOI: 10.3390/jcm11102709

Direct Current Electric Field Coordinates the Migration of BV2 Microglia via ERK/GSK3β/Cofilin Signaling Pathway.

Ma Y, Yang C, Liang Q, He Z, Weng W, Lei J, Skudder-Hill L, Jiang J, Feng J.

Molecular Neurobiology. 2022;59(6):3665-3677

Junfeng Feng: Sole corresponding author

DOI: 10.1007/s12035-022-02815-5

Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury.

Wen L, Wang YD, Shen DF, Zheng PD, Tu MD, You WD, Zhu YR, Wang H, Feng JF, Yang XF.

Neural Regeneration Research. 2022;17(12):2717-2724

Junfeng Feng: Author

DOI: 10.4103/1673-5374.339489

Tailored Lipoprotein-Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor-Stimulated Macropinocytosis.

Jiang G, Chen H, Huang J, Song Q, Chen Y, Gu X, Jiang Z, Huang Y, Lin Y, Feng J, Jiang J, Bao Y, Zheng G, Chen J, Chen H, Gao X.

Advanced Science. 2020;7(5):1903290

Junfeng Feng: Author

DOI: 10.1002/advs.201903290

Tailored Reconstituted Lipoprotein for Site-Specific and Mitochondria-Targeted Cyclosporine A Delivery to Treat Traumatic Brain Injury.

Chen L, Song Q, Chen Y, Meng S, Zheng M, Huang J, Zhang Q, Jiang J, Feng J, Chen H, Jiang G, Gao X.

ACS Nano. 2020;14(6):6636-6648

Junfeng Feng: Author

DOI: 10.1021/acsnano.9b09186

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.

Xie BS, Wang YQ, Lin Y, Mao Q, Feng JF, Gao GY, Jiang JY.

CNS Neuroscience & Therapeutics. 2019;25(4):465-475

Junfeng Feng: Author

DOI: 10.1111/cns.13069

Steered migration and changed morphology of human astrocytes by an applied electric field.

Yang C, Wang L, Weng W, Wang S, Ma Y, Mao Q, Gao G, Chen R, Feng J.

Experimental Cell Research. 2019;374(2):282-289

Junfeng Feng: Author

DOI: 10.1016/j.yexcr.2018.11.029

Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats.

Xie BS, Wang YQ, Lin Y, Zhao CC, Mao Q, Feng JF, Cao JY, Gao GY, Jiang JY.

Journal of Neurotrauma. 2018;35(14):1659-1666

Junfeng Feng: Author

DOI: 10.1089/neu.2017.5468

Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice.

Wen L, You W, Wang H, Meng Y, Feng J, Yang X.

Journal of Neurotrauma. 2018;35(19):2330-2340

Junfeng Feng: Author

DOI: 10.1089/neu.2017.5540

Alteration in Long Non-Coding RNA Expression after Traumatic Brain Injury in Rats.

Wang CF, Zhao CC, Weng WJ, Lei J, Lin Y, Mao Q, Gao GY, Feng JF, Jiang JY.

Journal of Neurotrauma. 2017;34(13):2100-2108

Junfeng Feng: Co-corresponding author

DOI: 10.1089/neu.2016.4642

Differential radiation response between normal astrocytes and glioma cells revealed by comparative transcriptome analysis.

Gong L, Gu J, Ge J, Wu X, Zhang C, Yang C, Weng W, Gao G, Feng J, Mao Q.

OncoTargets and Therapy. 2017;10:5755-5764

Junfeng Feng: Author

DOI: 10.2147/ott.s144002

Electrical Guidance of Human Stem Cells in the Rat Brain.

Feng JF, Liu J, Zhang L, Jiang JY, Russell M, Lyeth BG, Nolta JA, Zhao M.

Stem Cell Reports. 2017;9(1):177-189

Junfeng Feng: Author

DOI: 10.1016/j.stemcr.2017.05.035

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis.

Huang JL, Jiang G, Song QX, Gu X, Hu M, Wang XL, Song HH, Chen LP, Lin YY, Jiang D, Chen J, Feng JF, Qiu YM, Jiang JY, Jiang XG, Chen HZ, Gao XL.

Nature Communications. 2017;8:15144

Junfeng Feng: Author

DOI: 10.1038/ncomms15144

Mild Hypothermia Promotes Pericontusion Neuronal Sprouting via Suppressing Suppressor of Cytokine Signaling 3 Expression after Moderate Traumatic Brain Injury.

Zhao CC, Wang CF, Li WP, Lin Y, Tang QL, Feng JF, Mao Q, Gao GY, Jiang JY.

Journal of Neurotrauma. 2017;34(8):1636-1644

Junfeng Feng: Author

DOI: 10.1089/neu.2016.4759

The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury.

Wang CF, Zhao CC, Jiang G, Gu X, Feng JF, Jiang JY.

Scientific Reports. 2016;6:37063

Junfeng Feng: Author

DOI: 10.1038/srep37063

Attenuation of Cell Death in Injured Cortex After Post-Traumatic Brain Injury Moderate Hypothermia: Possible Involvement of Autophagy Pathway.

Jin Y, Lin Y, Feng JF, Jia F, Gao G, Jiang JY.

World Neurosurgery. 2015;84(2):420-430

Junfeng Feng: Author

DOI: 10.1016/j.wneu.2015.03.039

Moderate Hypothermia Significantly Decreases Hippocampal Cell Death Involving Autophagy Pathway after Moderate Traumatic Brain Injury.

Jin Y, Lin Y, Feng JF, Jia F, Gao GY, Jiang JY.

Journal of Neurotrauma. 2015;32(14):1090-1100

Junfeng Feng: Author

DOI: 10.1089/neu.2014.3649

Blockage of the upregulation of voltage-gated sodium channel nav1.3 improves outcomes after experimental traumatic brain injury.

Huang XJ, Li WP, Lin Y, Feng JF, Jia F, Mao Q, Jiang JY.

Journal of Neurotrauma. 2014;31(4):346-357

Junfeng Feng: Author

DOI: 10.1089/neu.2013.2899

Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury.

Gurkoff GG, Gahan JD, Ghiasvand RT, Hunsaker MR, Van K, Feng JF, Shahlaie K, Berman RF, Lyeth BG, Folkerts MM.

Journal of Neurotrauma. 2013;30(4):292-300

Junfeng Feng: Author

DOI: 10.1089/neu.2012.2463

Expression of voltage-gated sodium channel Nav1.3 is associated with severity of traumatic brain injury in adult rats.

Huang XJ, Mao Q, Lin Y, Feng JF, Jiang JY.

Journal of Neurotrauma. 2013;30(1):39-46

Junfeng Feng: Author

DOI: 10.1089/neu.2012.2508

NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia.

Gurkoff GG, Feng JF, Van KC, Izadi A, Ghiasvand R, Shahlaie K, Song M, Lowe DA, Zhou J, Lyeth BG.

Brain research. 2013;1515:98-107

Junfeng Feng: Author

DOI: 10.1016/j.brainres.2013.03.043

Guided migration of neural stem cells derived from human embryonic stem cells by an electric field.

Feng JF, Liu J, Zhang XZ, Zhang L, Jiang JY, Nolta J, Zhao M.

Stem Cells. 2012;30(2):349-355

Junfeng Feng: Author

DOI: 10.1002/stem.779

NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia.

Feng JF, Gurkoff GG, Van KC, Song M, Lowe DA, Zhou J, Lyeth BG.

Brain research. 2012;1469:144-152

Junfeng Feng: Author

DOI: 10.1016/j.brainres.2012.06.021

Post-traumatic hypoxia exacerbates neuronal cell death in the hippocampus.

Feng JF, Zhao X, Gurkoff GG, Van KC, Shahlaie K, Lyeth BG.

Journal of Neurotrauma. 2012;29(6):1167-1179

Junfeng Feng: Author

DOI: 10.1089/neu.2011.1867

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI.

Feng JF, Van KC, Gurkoff GG, Kopriva C, Olszewski RT, Song M, Sun S, Xu M, Neale JH, Yuen PW, Lowe DA, Zhou J, Lyeth BG.

Brain research. 2011;1395:62-73

Junfeng Feng: Author

DOI: 10.1016/j.brainres.2011.04.022

Effect of therapeutic mild hypothermia on the genomics of the hippocampus after moderate traumatic brain injury in rats.

Feng JF, Zhang KM, Jiang JY, Gao GY, Fu X, Liang YM.

Neurosurgery. 2010;67(3):730-742

Junfeng Feng: Author

DOI: 10.1227/01.neu.0000378023.81727.6e

Bcl-2 gene therapy for apoptosis following traumatic brain injury.

Yang XF, Zheng XS, Liu WG, Feng JF.

Chinese Journal of Traumatology. 2006;9(5):276-281

Junfeng Feng: Author